Clomiphene Citrate versus Letrozole in the Treatment of Anovulatory Infertility: A Randomized Controlled Trial

Background: Ovulatory dysfunction accounts for 20-25% of the cases infertility. The main treatment modality anovulatory infertility is ovarian stimulation. Clomiphene citrate (CC) and letrozole (LET) are drugs choice but which best first line debatable. Objective: Compare outcome by CC LET. Method: A prospective randomized controlled trial including two groups subfertile patients was carried out at a tertiary care center were to either 50 mg (n=127) standard used as control LET 2.5 (n=121) drug off labelled, yet currently prescribed sub-fertile daily from 2nd 6th day menstrual cycle. Follicle number on 12, endometrial thickness, pregnancy rates multiple pregnancies assessed. data analyzed using MINITAB 14. Results: mature follicles count (>18mm) 12 not significantly different in (CC: 1.323± 0.935 LET: 1.175±0.797). However, mean thickness treated higher than group (0.7691±0.0887 cm 0.695± 0.134cm respectively). clinical rate (49% vs. 38%). There no significant difference miscarriage (16% both arms). Conclusions: enhances compared with ongoing rates. may be due its favorable effects receptivity owing less anti-estrogenic properties.